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TitleZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 2837-2848, Year 2024
Publish dateJul 22, 2023 (structure data deposition date)
AuthorsLi, Z. / Lu, W. / Beyett, T.S. / Ficarro, S.B. / Jiang, J. / Tse, J. / Kim, A.Y. / Marto, J.A. / Che, J. / Janne, P.A. ...Li, Z. / Lu, W. / Beyett, T.S. / Ficarro, S.B. / Jiang, J. / Tse, J. / Kim, A.Y. / Marto, J.A. / Che, J. / Janne, P.A. / Eck, M.J. / Zhang, T. / Gray, N.S.
External linksJ. Med. Chem. / PubMed:38300264
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-8tjl:
EGFR kinase in complex with pyrazolopyrimidine covalent inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals


ChemComp, No image

ChemComp-HZ6:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE inhibitor / EGFR / kinase / covalent inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE inhibitor complex

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