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-Structure paper
Title | Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 98, Page 117581-117581, Year 2023 |
Publish date | Nov 21, 2023 (structure data deposition date) |
![]() | Imaizumi, T. / Shimada, I. / Satake, Y. / Yamaki, S. / Koike, T. / Nigawara, T. / Kaneko, O. / Amano, Y. / Mori, K. / Yamanaka, Y. ...Imaizumi, T. / Shimada, I. / Satake, Y. / Yamaki, S. / Koike, T. / Nigawara, T. / Kaneko, O. / Amano, Y. / Mori, K. / Yamanaka, Y. / Nakayama, A. / Nishizono, Y. / Shimazaki, M. / Nagashima, T. / Kuramoto, K. |
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Methods | X-ray diffraction |
Resolution | 1.85 Å |
Structure data | ![]() PDB-8x6r: |
Chemicals | ![]() ChemComp-GDP: ![]() ChemComp-MG: ![]() ChemComp-Y9D: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/INHIBITOR / GTP-binding / HYDROLASE-INHIBITOR COMPLEX |