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| Title | Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors. |
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| Journal, issue, pages | Bioorg. Med. Chem., Vol. 98, Page 117581-117581, Year 2023 |
| Publish date | Nov 21, 2023 (structure data deposition date) |
 Authors | Imaizumi, T. / Shimada, I. / Satake, Y. / Yamaki, S. / Koike, T. / Nigawara, T. / Kaneko, O. / Amano, Y. / Mori, K. / Yamanaka, Y. ...Imaizumi, T. / Shimada, I. / Satake, Y. / Yamaki, S. / Koike, T. / Nigawara, T. / Kaneko, O. / Amano, Y. / Mori, K. / Yamanaka, Y. / Nakayama, A. / Nishizono, Y. / Shimazaki, M. / Nagashima, T. / Kuramoto, K. |
 External links | Bioorg. Med. Chem. / PubMed:38176113 |
| Methods | X-ray diffraction |
| Resolution | 1.85 Å |
| Structure data |  PDB-8x6r: |
| Chemicals |  ChemComp-GDP:  ChemComp-MG:  ChemComp-Y9D:  ChemComp-HOH: |
| Source |
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 Keywords | HYDROLASE/INHIBITOR / GTP-binding / HYDROLASE-INHIBITOR COMPLEX |
homo sapiens (human)