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TitleFrom Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 754-773, Year 2024
Publish dateApr 26, 2022 (structure data deposition date)
AuthorsZhang, L. / Li, Y. / Tian, C. / Yang, R. / Wang, Y. / Xu, H. / Zhu, Q. / Chen, S. / Li, L. / Yang, S.
External linksJ. Med. Chem. / PubMed:38159286
MethodsX-ray diffraction
Resolution2.376 Å
Structure data

PDB-7xmk:
Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923
Method: X-RAY DIFFRACTION / Resolution: 2.376 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-GO4:
5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / RIPK1 / kinase / complex / inhibitor

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