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-Structure paper
Title | Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders. |
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Journal, issue, pages | Angew. Chem. Int. Ed. Engl., Vol. 63, Page e202316730-e202316730, Year 2024 |
Publish date | Jul 11, 2023 (structure data deposition date) |
Authors | Barbosa, B.M.G. / Sfyaki, A. / Rafael, S. / Jose-Duran, F. / Pous, J. / Sanchez-Zarzalejo, C. / Perez-Lopez, C. / Vilanova, M. / Cigler, M. / Gay, M. ...Barbosa, B.M.G. / Sfyaki, A. / Rafael, S. / Jose-Duran, F. / Pous, J. / Sanchez-Zarzalejo, C. / Perez-Lopez, C. / Vilanova, M. / Cigler, M. / Gay, M. / Vilaseca, M. / Winter, G.E. / Riera, A. / Mayor-Ruiz, C. |
External links | Angew. Chem. Int. Ed. Engl. / PubMed:38153885 |
Methods | X-ray diffraction |
Resolution | 3.8 Å |
Structure data | PDB-8pqn: |
Chemicals | ChemComp-FAD: ChemComp-978: |
Source |
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Keywords | OXIDOREDUCTASE / NQO1 / RBS-10 / quinone reductase / degrader resistance / prodrug |