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TitleNew cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease.
Journal, issue, pagesBrain, Vol. 147, Page 1710-1725, Year 2024
Publish dateSep 19, 2022 (structure data deposition date)
AuthorsSamanta, S. / Akhter, F. / Roy, A. / Chen, D. / Turner, B. / Wang, Y. / Clemente, N. / Wang, C. / Swerdlow, R.H. / Battaile, K.P. ...Samanta, S. / Akhter, F. / Roy, A. / Chen, D. / Turner, B. / Wang, Y. / Clemente, N. / Wang, C. / Swerdlow, R.H. / Battaile, K.P. / Lovell, S. / Yan, S.F. / Yan, S.S.
External linksBrain / PubMed:38146639
MethodsX-ray diffraction
Resolution1.65 Å
Structure data

PDB-8ejx:
Crystal structure of human cyclophilin D (CypD) with in complex with the covalently bound Ebselen inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-9JT:
N-phenyl-2-selanylbenzamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsISOMERASE

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