+Search query
-Structure paper
Title | Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity. |
---|---|
Journal, issue, pages | Acs Med. Chem. Lett., Vol. 14, Page 1848-1856, Year 2023 |
Publish date | Sep 26, 2023 (structure data deposition date) |
![]() | Boerth, J.A. / Chinn, A.J. / Schimpl, M. / Bommakanti, G. / Chan, C. / Code, E.L. / Giblin, K.A. / Gohlke, A. / Hansel, C.S. / Jin, M. ...Boerth, J.A. / Chinn, A.J. / Schimpl, M. / Bommakanti, G. / Chan, C. / Code, E.L. / Giblin, K.A. / Gohlke, A. / Hansel, C.S. / Jin, M. / Kavanagh, S.L. / Lamb, M.L. / Lane, J.S. / Larner, C.J.B. / Mfuh, A.M. / Moore, R.K. / Puri, T. / Quinn, T.R. / Ye, M. / Robbins, K.J. / Gancedo-Rodrigo, M. / Tang, H. / Walsh, J. / Ware, J. / Wrigley, G.L. / Reddy, I.K. / Zhang, Y. / Grimster, N.P. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.001 - 2.483 Å |
Structure data | ![]() PDB-8qng: ![]() PDB-8qnh: ![]() PDB-8qni: |
Chemicals | ![]() ChemComp-W89: ![]() ChemComp-ZN: ![]() ChemComp-NA: ![]() ChemComp-HOH: ![]() ChemComp-Z3N: ![]() ChemComp-W7R: |
Source |
|
![]() | LIGASE / E3 Ubiquitin ligase / allosteric inhibition / structure based drug design |