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Structure paper

TitleOptical Control of Proteasomal Protein Degradation with a Photoswitchable Lipopeptide.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 63, Page e202314791-e202314791, Year 2024
Publish dateMar 21, 2023 (structure data deposition date)
AuthorsMorstein, J. / Amatuni, A. / Shuster, A. / Kuttenlochner, W. / Ko, T. / Abegg, D. / Groll, M. / Adibekian, A. / Renata, H. / Trauner, D.H.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:38109686
MethodsX-ray diffraction
Resolution2.65 - 2.95 Å
Structure data

PDB-8ohz:
Yeast 20S proteasome in complex with a photoswitchable cepafungin derivative (transCep1)
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-8oi1:
Yeast 20S proteasome in complex with a photoswitchable cepafungin derivative (transCep4)
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-VOT:
(2~{S},3~{R})-2-[2-[4-[2-(4-ethylphenyl)hydrazinyl]phenyl]ethanoylamino]-~{N}-[(5~{S},8~{S},10~{S})-5-methyl-10-oxidanyl-2,7-bis(oxidanylidene)-1,6-diazacyclododec-8-yl]-3-oxidanyl-butanamide

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-VOX:
~{N}-[(2~{S},3~{R})-1-[[(5~{S},8~{S},10~{S})-5-methyl-10-oxidanyl-2,7-bis(oxidanylidene)-1,6-diazacyclododec-8-yl]amino]-3-oxidanyl-1-oxidanylidene-butan-2-yl]-7-[4-[2-(4-methylphenyl)hydrazinyl]phenyl]heptanamide

ChemComp-SO4:
SULFATE ION

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsHYDROLASE / Proteasome / Syrbactins / Photoswitchable Lipid / Binding Analysis

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