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| Title | Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 67, Page 3307-3320, Year 2024 |
| Publish date | Sep 20, 2023 (structure data deposition date) |
Authors | Gunasekaran, P. / Hwang, Y.S. / Lee, G.H. / Park, J. / Kim, J.G. / La, Y.K. / Park, N.Y. / Kothandaraman, R. / Yim, M.S. / Choi, J. ...Gunasekaran, P. / Hwang, Y.S. / Lee, G.H. / Park, J. / Kim, J.G. / La, Y.K. / Park, N.Y. / Kothandaraman, R. / Yim, M.S. / Choi, J. / Kim, H.N. / Park, I.Y. / Lee, S.J. / Kim, M.H. / Cha-Molstad, H. / Shin, S.Y. / Ryu, E.K. / Bang, J.K. |
External links | J. Med. Chem. / PubMed:38105611 |
| Methods | X-ray diffraction |
| Resolution | 1.99 Å |
| Structure data | ![]() PDB-8wfp: |
| Chemicals | ![]() ChemComp-HOH: |
| Source |
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Keywords | STRUCTURAL PROTEIN / Inhibitor |
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homo sapiens (human)
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