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TitleDiscovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer.
Journal, issue, pagesMabs, Vol. 15, Page 2289681-2289681, Year 2023
Publish dateSep 30, 2022 (structure data deposition date)
AuthorsDavies, G.C.G. / Dedi, N. / Jones, P.S. / Kevorkian, L. / McMillan, D. / Ottone, C. / Schulze, M.E.D. / Scott-Tucker, A. / Tewari, R. / West, S. ...Davies, G.C.G. / Dedi, N. / Jones, P.S. / Kevorkian, L. / McMillan, D. / Ottone, C. / Schulze, M.E.D. / Scott-Tucker, A. / Tewari, R. / West, S. / Wright, M. / Rowley, T.F.
External linksMabs / PubMed:38084840
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-8b7h:
Crystal structure of human Gremlin-1 in complex with Fab
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Inhibitor / glycoprotein / cysteine knot-secreted protein

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