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TitleAntigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity.
Journal, issue, pagesSignal Transduct Target Ther, Vol. 8, Page 445-445, Year 2023
Publish dateJan 5, 2023 (structure data deposition date)
AuthorsSun, Y. / Yang, X.N. / Yang, S.S. / Lyu, Y.Z. / Zhang, B. / Liu, K.W. / Li, N. / Cui, J.C. / Huang, G.X. / Liu, C.L. ...Sun, Y. / Yang, X.N. / Yang, S.S. / Lyu, Y.Z. / Zhang, B. / Liu, K.W. / Li, N. / Cui, J.C. / Huang, G.X. / Liu, C.L. / Xu, J. / Mi, J.Q. / Chen, Z. / Fan, X.H. / Chen, S.J. / Chen, S.
External linksSignal Transduct Target Ther / PubMed:38062078
MethodsX-ray diffraction
Resolution2.4 - 2.7 Å
Structure data

PDB-8hxq:
Nanobody1 in complex with human BCMA ECD
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-8hxr:
Nanobody2 in complex with human BCMA ECD
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • vicugna pacos (alpaca)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / complex / Nanobody

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