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TitleChemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate.
Journal, issue, pagesJ. Med. Chem., Vol. 66, Page 15648-15670, Year 2023
Publish dateMay 9, 2023 (structure data deposition date)
AuthorsLindberg, M.F. / Deau, E. / Miege, F. / Greverie, M. / Roche, D. / George, N. / George, P. / Merlet, L. / Gavard, J. / Brugman, S.J.T. ...Lindberg, M.F. / Deau, E. / Miege, F. / Greverie, M. / Roche, D. / George, N. / George, P. / Merlet, L. / Gavard, J. / Brugman, S.J.T. / Aret, E. / Tinnemans, P. / de Gelder, R. / Sadownik, J. / Verhofstad, E. / Sleegers, D. / Santangelo, S. / Dairou, J. / Fernandez-Blanco, A. / Dierssen, M. / Kramer, A. / Knapp, S. / Meijer, L.
External linksJ. Med. Chem. / PubMed:38051674
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-8p08:
Crystal structure of human CLK1 in complex with Leucettinib-21
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-WAZ:
(4~{Z})-4-(1,3-benzothiazol-6-ylmethylidene)-2-[[(2~{R})-1-methoxy-4-methyl-pentan-2-yl]amino]-1~{H}-imidazol-5-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase / Typ1 inhibitor / CLK1 / Structural Genomics / Structural Genomics Consortium / SGC

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