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-Structure paper
Title | Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha. |
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Journal, issue, pages | Chem Sci, Vol. 14, Page 12098-12120, Year 2023 |
Publish date | Jul 26, 2023 (structure data deposition date) |
Authors | Corner, T.P. / Teo, R.Z.R. / Wu, Y. / Salah, E. / Nakashima, Y. / Fiorini, G. / Tumber, A. / Brasnett, A. / Holt-Martyn, J.P. / Figg Jr., W.D. ...Corner, T.P. / Teo, R.Z.R. / Wu, Y. / Salah, E. / Nakashima, Y. / Fiorini, G. / Tumber, A. / Brasnett, A. / Holt-Martyn, J.P. / Figg Jr., W.D. / Zhang, X. / Brewitz, L. / Schofield, C.J. |
External links | Chem Sci / PubMed:37969593 |
Methods | X-ray diffraction |
Resolution | 2.02 - 2.45 Å |
Structure data | PDB-8k71: PDB-8k72: PDB-8k73: |
Chemicals | ChemComp-ZN: ChemComp-VIZ: ChemComp-SO4: ChemComp-GOL: ChemComp-HOH: ChemComp-VJF: ChemComp-VK6: |
Source |
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Keywords | OXIDOREDUCTASE / factor-inhibiting hypoxia-inducible factor / FIH / 2OG dependent dioxygenase |