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Title | Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 15380-15408, Year 2023 |
Publish date | Jul 29, 2023 (structure data deposition date) |
![]() | Green, S.R. / Wilson, C. / Eadsforth, T.C. / Punekar, A.S. / Tamaki, F.K. / Wood, G. / Caldwell, N. / Forte, B. / Norcross, N.R. / Kiczun, M. ...Green, S.R. / Wilson, C. / Eadsforth, T.C. / Punekar, A.S. / Tamaki, F.K. / Wood, G. / Caldwell, N. / Forte, B. / Norcross, N.R. / Kiczun, M. / Post, J.M. / Lopez-Roman, E.M. / Engelhart, C.A. / Lukac, I. / Zuccotto, F. / Epemolu, O. / Boshoff, H.I.M. / Schnappinger, D. / Walpole, C. / Gilbert, I.H. / Read, K.D. / Wyatt, P.G. / Baragana, B. |
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Methods | X-ray diffraction |
Resolution | 1.71 - 1.8 Å |
Structure data | ![]() PDB-8q0t: ![]() PDB-8q0u: ![]() PDB-8q17: |
Chemicals | ![]() ChemComp-IJJ: ![]() ChemComp-HOH: ![]() ChemComp-SO4: ![]() ChemComp-IKG: ![]() ChemComp-IL8: ![]() ChemComp-GOL: ![]() ChemComp-2Q5: |
Source |
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