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Structure paper

TitleStructural insights into asymmetric activation of the calcium-sensing receptor-G complex.
Journal, issue, pagesCell Res, Vol. 34, Issue 2, Page 169-172, Year 2024
Publish dateNov 2, 2023
AuthorsShenglong Ling / Xianyu Meng / Yuan Zhang / Zhemin Xia / Yingxin Zhou / Fan Yang / Pan Shi / Chaowei Shi / Changlin Tian /
External linksCell Res / PubMed:37919470 / PubMed Central
MethodsEM (single particle)
Resolution2.7 - 3.1 Å
Structure data

37716

8wpg

EMDB-37716, PDB-8wpg:
Human calcium-sensing receptor bound with cinacalcet in detergent
Method: EM (single particle) / Resolution: 2.7 Å

37724

8wpu

EMDB-37724, PDB-8wpu:
Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-TRP:
TRYPTOPHAN

ChemComp-CA:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-YP4:
N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine

ChemComp-CLR:
CHOLESTEROL

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / GPCR / allosteric modulator / activation / dimeric / GPCR-G protein complex

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