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-Structure paper
タイトル | Architecture of the bacteriophage lambda tail. |
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ジャーナル・号・ページ | Structure, Vol. 32, Issue 1, Page 35-46.e3, Year 2024 |
掲載日 | 2024年1月4日 |
著者 | Chang Wang / Jinsong Duan / Zhiwei Gu / Xiaofei Ge / Jianwei Zeng / Jiawei Wang / |
PubMed 要旨 | Bacteriophage lambda has a double-stranded DNA genome and a long, flexible, non-contractile tail encoded by a contiguous block of 11 genes downstream of the head genes. The tail allows host ...Bacteriophage lambda has a double-stranded DNA genome and a long, flexible, non-contractile tail encoded by a contiguous block of 11 genes downstream of the head genes. The tail allows host recognition and delivery of viral DNA from the head shell to the cytoplasm of the infected cell. Here, we present a high-resolution structure of the tail complex of bacteriophage lambda determined by cryoelectron microscopy. Most component proteins of the lambda tail were determined at the atomic scale. The structure sheds light on the molecular organization of the extensively studied tail of bacteriophage lambda. |
リンク | Structure / PubMed:37918400 |
手法 | EM (単粒子) |
解像度 | 2.95 - 6.07 Å |
構造データ | EMDB-35818, PDB-8iyd: EMDB-35824, PDB-8iyk: EMDB-35825, PDB-8iyl: EMDB-35826: Tail fiber of phage lambda tail EMDB-36677, PDB-8jvm: EMDB-37218, PDB-8kge: |
化合物 | ChemComp-SF4: |
由来 |
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キーワード | VIRAL PROTEIN / Bacteriophage / caudovirales / siphoviridae / tail complex / delivery device / macromolecular assembly / phage lambda / cryo-EM |