+Search query
-Structure paper
Title | Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. |
---|---|
Journal, issue, pages | Commun Med (Lond), Vol. 3, Page 154-154, Year 2023 |
Publish date | Sep 22, 2022 (structure data deposition date) |
Authors | Yuda, J. / Will, C. / Phillips, D.C. / Abraham, L. / Alvey, C. / Avigdor, A. / Buck, W. / Besenhofer, L. / Boghaert, E. / Cheng, D. ...Yuda, J. / Will, C. / Phillips, D.C. / Abraham, L. / Alvey, C. / Avigdor, A. / Buck, W. / Besenhofer, L. / Boghaert, E. / Cheng, D. / Cojocari, D. / Doyle, K. / Hansen, T.M. / Huang, K. / Johnson, E.F. / Judd, A.S. / Judge, R.A. / Kalvass, J.C. / Kunzer, A. / Lam, L.T. / Li, R. / Martin, R.L. / Mastracchio, A. / Mitten, M. / Petrich, A. / Wang, J. / Ward, J.E. / Zhang, H. / Wang, X. / Wolff, J.E. / Bell-McGuinn, K.M. / Souers, A.J. |
External links | Commun Med (Lond) / PubMed:37880389 |
Methods | X-ray diffraction |
Resolution | 1.55 - 2.406 Å |
Structure data | PDB-8ekx: PDB-8el0: PDB-8el1: |
Chemicals | ChemComp-OK5: ChemComp-HOH: ChemComp-WLW: ChemComp-WME: |
Source |
|
Keywords | APOPTOSIS / MBP-Mcl-1 fusion protein / MIK665 / inhibitor complex / ABBV-467 |