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-Structure paper
Title | X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles. |
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Journal, issue, pages | Bioorg. Chem., Vol. 141, Page 106919-106919, Year 2023 |
Publish date | Jan 19, 2022 (structure data deposition date) |
![]() | Bai, C. / Lv, Y. / Xiong, S. / Wu, S. / Qi, L. / Ren, S. / Zhu, M. / Dong, H. / Shen, H. / Li, Z. ...Bai, C. / Lv, Y. / Xiong, S. / Wu, S. / Qi, L. / Ren, S. / Zhu, M. / Dong, H. / Shen, H. / Li, Z. / Zhu, Y. / Ye, H. / Hao, H. / Xiao, Y. / Xiang, H. / Luo, G. |
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Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | ![]() PDB-7wnv: |
Chemicals | ![]() ChemComp-2I9: ![]() ChemComp-HOH: |
Source |
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![]() | NUCLEAR PROTEIN / Covalent Inhibitor Transcription factor Oncogene |