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Structure paper

TitleMolecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids.
Journal, issue, pagesNucleic Acids Res., Vol. 51, Page 11927-11940, Year 2023
Publish dateNov 1, 2022 (structure data deposition date)
AuthorsHuang, K.W. / Wu, C.Y. / Toh, S.I. / Liu, T.C. / Tu, C.I. / Lin, Y.H. / Cheng, A.J. / Kao, Y.T. / Chu, J.W. / Hsiao, Y.Y.
External linksNucleic Acids Res. / PubMed:37870446
MethodsX-ray diffraction
Resolution1.501 - 2 Å
Structure data

PDB-8hcc:
Crystal structure of mTREX1-RNA product complex (AMP)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8hcd:
Crystal structure of mTREX1-DNA product complex (dNMP)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8hce:
Crystal structure of mTREX1-CMP complex
Method: X-RAY DIFFRACTION / Resolution: 1.501 Å

PDB-8hcf:
Crystal structure of mTREX1-UMP complex
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-8hcg:
Crystal structure of mTREX1-dAMP complex
Method: X-RAY DIFFRACTION / Resolution: 1.799 Å

PDB-8hch:
Crystal structure of mTREX1-Uridine complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DCM:
2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE

ChemComp-DGP:
2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE

ChemComp-CO:
Unknown entry

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-NH4:
AMMONIUM ION

ChemComp-C5P:
CYTIDINE-5'-MONOPHOSPHATE

ChemComp-U5P:
URIDINE-5'-MONOPHOSPHATE

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-D5M:
2'-DEOXYADENOSINE-5'-MONOPHOSPHATE

ChemComp-URI:
URIDINE

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / TREX1 / DEDDh exonuclease / DNase / RNase / AMP / dCMP / dGMP / CMP / UMP / dAMP / Uridine

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