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TitleAn allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.
Journal, issue, pagesNat Commun, Vol. 14, Page 6548-6548, Year 2023
Publish dateJun 10, 2021 (structure data deposition date)
AuthorsCuesta-Hernandez, H.N. / Contreras, J. / Soriano-Maldonado, P. / Sanchez-Wandelmer, J. / Yeung, W. / Martin-Hurtado, A. / Munoz, I.G. / Kannan, N. / Llimargas, M. / Munoz, J. / Plaza-Menacho, I.
External linksNat Commun / PubMed:37848415
MethodsX-ray diffraction
Resolution2.49 Å
Structure data

PDB-7ote:
Src Kinase Domain in complex with ponatinib
Method: X-RAY DIFFRACTION / Resolution: 2.49 Å

Chemicals

ChemComp-0LI:
3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam / medication*YM

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / ATP Inhibitor / Kinase / ligand binding / Cell signalling

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