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TitleA conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.
Journal, issue, pagesNucleic Acids Res., Vol. 51, Page 11893-11910, Year 2023
Publish dateDec 15, 2020 (structure data deposition date)
Authorsde Regt, A.K. / Anand, K. / Ciupka, K. / Bender, F. / Gatterdam, K. / Putschli, B. / Fussholler, D. / Hilbig, D. / Kirchhoff, A. / Hunkler, C. ...de Regt, A.K. / Anand, K. / Ciupka, K. / Bender, F. / Gatterdam, K. / Putschli, B. / Fussholler, D. / Hilbig, D. / Kirchhoff, A. / Hunkler, C. / Wolter, S. / Grunewald, A. / Wallerath, C. / Schuberth-Wagner, C. / Ludwig, J. / Paeschke, K. / Bartok, E. / Hagelueken, G. / Hartmann, G. / Zillinger, T. / Geyer, M. / Schlee, M.
External linksNucleic Acids Res. / PubMed:37831086
MethodsX-ray diffraction
Resolution1.89 - 3.4 Å
Structure data

PDB-7bah:
Structure of RIG-I CTD bound to OH-RNA
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

PDB-7bai:
Structure of RIG-I CTD (I875A) bound to p-RNA
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / RNA recognition / innate immunity

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