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TitleBiophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.
Journal, issue, pagesJ. Biol. Chem., Vol. 299, Page 105328-105328, Year 2023
Publish dateAug 25, 2022 (structure data deposition date)
AuthorsGradler, U. / Schwarz, D. / Wegener, A. / Eichhorn, T. / Bandeiras, T.M. / Freitas, M.C. / Lammens, A. / Ganichkin, O. / Augustin, M. / Minguzzi, S. ...Gradler, U. / Schwarz, D. / Wegener, A. / Eichhorn, T. / Bandeiras, T.M. / Freitas, M.C. / Lammens, A. / Ganichkin, O. / Augustin, M. / Minguzzi, S. / Becker, F. / Bomke, J.
External linksJ. Biol. Chem. / PubMed:37806493
MethodsX-ray diffraction
Resolution2.14 - 2.72 Å
Structure data

PDB-8au3:
c-MET Y1234E,Y1235E mutant in complex with Tepotinib
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

PDB-8au5:
c-MET F1200I mutant in complex with Tepotinib
Method: X-RAY DIFFRACTION / Resolution: 2.72 Å

PDB-8aw1:
c-MET Y1235D mutant in complex with Tepotinib
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

Chemicals

ChemComp-3E8:
3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PROTEIN KINASE

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