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TitleEvaluation of in vitro antiviral activity of SARS-CoV-2 M pro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions.
Journal, issue, pagesAntimicrob. Agents Chemother., Vol. 67, Page e0084023-e0084023, Year 2023
Publish dateJun 28, 2023 (structure data deposition date)
AuthorsTong, X. / Keung, W. / Arnold, L.D. / Stevens, L.J. / Pruijssers, A.J. / Kook, S. / Lopatin, U. / Denison, M. / Kwong, A.D.
External linksAntimicrob. Agents Chemother. / PubMed:37800975
MethodsX-ray diffraction
Resolution2.15 Å
Structure data

PDB-8tbe:
Co-crystal structure of SARS-CoV-2 Mpro with Pomotrelvir
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-ZQB:
Pomotrelvir bound form

ChemComp-HOH:
WATER

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / main protease / 3cl protease

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