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TitleATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1.
Journal, issue, pagesCancer Immunol. Immunother., Vol. 72, Page 4145-4159, Year 2023
Publish dateMay 8, 2023 (structure data deposition date)
AuthorsEnell Smith, K. / Fritzell, S. / Nilsson, A. / Barchan, K. / Rosen, A. / Schultz, L. / Varas, L. / Sall, A. / Rose, N. / Hakansson, M. ...Enell Smith, K. / Fritzell, S. / Nilsson, A. / Barchan, K. / Rosen, A. / Schultz, L. / Varas, L. / Sall, A. / Rose, N. / Hakansson, M. / von Schantz, L. / Ellmark, P.
External linksCancer Immunol. Immunother. / PubMed:37796298
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-8oz3:
Crystal structure of scFv ATOR 1017 bound to human 4-1BB
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / complex / single chain Fv / tumor necrosis factor

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