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TitleEvaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.
Journal, issue, pagesEur. J. Med. Chem., Vol. 261, Page 115779-115779, Year 2023
Publish dateSep 30, 2022 (structure data deposition date)
AuthorsMersal, K.I. / Abdel-Maksoud, M.S. / Ali, E.M.H. / Ammar, U.M. / Zaraei, S.O. / Haque, M.M. / Das, T. / Hassan, N.F. / Kim, E.E. / Lee, J.S. ...Mersal, K.I. / Abdel-Maksoud, M.S. / Ali, E.M.H. / Ammar, U.M. / Zaraei, S.O. / Haque, M.M. / Das, T. / Hassan, N.F. / Kim, E.E. / Lee, J.S. / Park, H. / Lee, K.H. / El-Gamal, M.I. / Kim, H.K. / Ibrahim, T.M. / Oh, C.H.
External linksEur. J. Med. Chem. / PubMed:37776574
MethodsX-ray diffraction
Resolution2.81 Å
Structure data

PDB-8enj:
Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK)
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-WNK:
N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Cancer / JNK / Leukemia

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