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TitleAffimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition.
Journal, issue, pagesCell Rep, Vol. 42, Page 113184-113184, Year 2023
Publish dateDec 19, 2022 (structure data deposition date)
AuthorsMartin, H.L. / Turner, A.L. / Higgins, J. / Tang, A.A. / Tiede, C. / Taylor, T. / Siripanthong, S. / Adams, T.L. / Manfield, I.W. / Bell, S.M. ...Martin, H.L. / Turner, A.L. / Higgins, J. / Tang, A.A. / Tiede, C. / Taylor, T. / Siripanthong, S. / Adams, T.L. / Manfield, I.W. / Bell, S.M. / Morrison, E.E. / Bond, J. / Trinh, C.H. / Hurst, C.D. / Knowles, M.A. / Bayliss, R.W. / Tomlinson, D.C.
External linksCell Rep / PubMed:37776520
MethodsX-ray diffraction
Resolution1.549 Å
Structure data

PDB-8c12:
Identification of an intermediate activation state of PAK5 reveals a novel mechanism of kinase inhibition.
Method: X-RAY DIFFRACTION / Resolution: 1.549 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE / Kinase / PAK5 / Affimer / Urothelial cancer.

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