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Title | Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 13384-13399, Year 2023 |
Publish date | Jun 15, 2023 (structure data deposition date) |
Authors | Taylor, A.M. / Williams, B.R. / Giordanetto, F. / Kelley, E.H. / Lescarbeau, A. / Shortsleeves, K. / Tang, Y. / Walters, W.P. / Arrazate, A. / Bowman, C. ...Taylor, A.M. / Williams, B.R. / Giordanetto, F. / Kelley, E.H. / Lescarbeau, A. / Shortsleeves, K. / Tang, Y. / Walters, W.P. / Arrazate, A. / Bowman, C. / Brophy, E. / Chan, E.W. / Deshmukh, G. / Greisman, J.B. / Hunsaker, T.L. / Kipp, D.R. / Saenz Lopez-Larrocha, P. / Maddalo, D. / Martin, I.J. / Maragakis, P. / Merchant, M. / Murcko, M. / Nisonoff, H. / Nguyen, V. / Orozco, O. / Owen, C. / Pierce, L. / Schmidt, M. / Shaw, D.E. / Smith, S. / Therrien, E. / Tran, J.C. / Watters, J. / Waters, N.J. / Wilbur, J. / Willmore, L. |
External links | J. Med. Chem. / PubMed:37774359 |
Methods | X-ray diffraction |
Resolution | 1.84 - 2.4 Å |
Structure data | PDB-8t6d: PDB-8t6g: PDB-8t7q: PDB-8t8q: |
Chemicals | ChemComp-SO4: ChemComp-YR2: ChemComp-HOH: ChemComp-YT2: ChemComp-ZH5: ChemComp-ZJX: |
Source |
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Keywords | HYDROLASE / Phosphatase / Tumor target / inhibitor / HYDROLASE/INHIBITOR / HYDROLASE-INHIBITOR complex |