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Structure paper

TitleMolecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.
Journal, issue, pagesStructure, Vol. 31, Page 1441-, Year 2023
Publish dateJun 1, 2023 (structure data deposition date)
AuthorsWang, G. / Feng, X. / Ding, J.
External linksStructure / PubMed:37683642
MethodsX-ray diffraction
Resolution2.92 - 3.3 Å
Structure data

PDB-8jkl:
IRF4 DNA-binding domain bound to an DNA containing GATA motif
Method: X-RAY DIFFRACTION / Resolution: 2.94 Å

PDB-8jkn:
T95R mutant IRF4 DNA-binding domain bound to an DNA containing GAAA motif
Method: X-RAY DIFFRACTION / Resolution: 2.92 Å

PDB-8jko:
T95R mutant IRF4 DNA-binding domain bound to an DNA containing GATA motif
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-8jkq:
T95R mutant IRF4 DNA-binding domain bound to an DNA containing GACA motif
Method: X-RAY DIFFRACTION / Resolution: 3.09 Å

PDB-8jks:
T95R mutant IRF4 DNA-binding domain bound to an DNA containing GAGA motif
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / IRF4 / transcription factor / protein-DNA complex

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