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Structure paper

TitleStructural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy.
Journal, issue, pagesIscience, Vol. 26, Page 107672-107672, Year 2023
Publish dateFeb 12, 2022 (structure data deposition date)
AuthorsGuo, W. / Li, X. / Fan, J. / Li, H. / Wen, Y. / Meng, C. / Chen, H. / Zhao, Z. / Zhang, Y. / Du, Y. / Wu, B.
External linksIscience / PubMed:37680460
MethodsX-ray diffraction
Resolution1.9 - 2.7 Å
Structure data

PDB-7ww2:
Structure of an Isocytosine specific deaminase Vcz
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-8is4:
Structure of an Isocytosine specific deaminase Vcz in complexed with 5-FU
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8is5:
Structure of an Isocytosine specific deaminase Vcz with close state
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-URF:
5-FLUOROURACIL / medication, chemotherapy*YM

ChemComp-GOL:
GLYCEROL

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-SO4:
SULFATE ION

Source
  • obesumbacterium proteus (bacteria)
KeywordsHYDROLASE / deaminase / isocytosine / cancer therapy / 5-fluorouracil / VCZ / 5-FU

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