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Title | Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 13172-13188, Year 2023 |
Publish date | May 8, 2023 (structure data deposition date) |
Authors | Liu, J. / Cheng, Y. / Yuan, L. / Liu, T. / Ruan, Y. / Ren, Y. / Li, L. / Jiang, S. / Xiao, Y. / Chen, J. |
External links | J. Med. Chem. / PubMed:37674362 |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-8jba: |
Chemicals | ChemComp-AU9: ChemComp-HOH: |
Source |
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Keywords | IMMUNE SYSTEM / Immune checkpoint / Dimer / Inhibitor |