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Structure paper

TitleHomoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma.
Journal, issue, pagesBiomed Pharmacother, Vol. 166, Page 115429-115429, Year 2023
Publish dateMay 25, 2021 (structure data deposition date)
AuthorsHsieh, C.H. / Huang, C.T. / Cheng, Y.S. / Hsu, C.H. / Hsu, W.M. / Chung, Y.H. / Liu, Y.L. / Yang, T.S. / Chien, C.Y. / Lee, Y.H. ...Hsieh, C.H. / Huang, C.T. / Cheng, Y.S. / Hsu, C.H. / Hsu, W.M. / Chung, Y.H. / Liu, Y.L. / Yang, T.S. / Chien, C.Y. / Lee, Y.H. / Huang, H.C. / Juan, H.F.
External linksBiomed Pharmacother / PubMed:37673018
MethodsX-ray diffraction
Resolution2.99 Å
Structure data

PDB-7ewh:
Crystal structure of human PHGDH in complex with Homoharringtonine
Method: X-RAY DIFFRACTION / Resolution: 2.99 Å

Chemicals

ChemComp-HMT:
(3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine / alkaloid*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / inhibitor

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