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TitleRationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding.
Journal, issue, pagesChem Sci, Vol. 14, Page 8269-8278, Year 2023
Publish dateDec 6, 2022 (structure data deposition date)
AuthorsSchmeing, S. / Amrahova, G. / Bigler, K. / Chang, J.Y. / Openy, J. / Pal, S. / Posada, L. / Gasper, R. / 't Hart, P.
External linksChem Sci / PubMed:37564416
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-8bwf:
PTBP1 RRM1 bound to an allosteric inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NH2:
AMINO GROUP

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / RNA binding / protein-peptide interaction / inhibitor

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