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Structure paper

TitleMolecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 30, Page 1265-1274, Year 2023
Publish dateJan 29, 2022 (structure data deposition date)
AuthorsTencer, A.H. / Yu, Y. / Causse, S.Z. / Campbell, G.R. / Klein, B.J. / Xuan, H. / Cartier, J. / Miles, M.A. / Gaurav, N. / Zadoroznyj, A. ...Tencer, A.H. / Yu, Y. / Causse, S.Z. / Campbell, G.R. / Klein, B.J. / Xuan, H. / Cartier, J. / Miles, M.A. / Gaurav, N. / Zadoroznyj, A. / Holt, T.A. / Wen, H. / Hawkins, C.J. / Spector, S.A. / Dubrez, L. / Shi, X. / Kutateladze, T.G.
External linksNat. Struct. Mol. Biol. / PubMed:37524969
MethodsX-ray diffraction
Resolution1.74 - 2.4 Å
Structure data

PDB-7trl:
Crystal structure of human BIRC2 BIR3 domain in complex with histone H3
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-7trm:
Crystal structure of human BIRC2 BIR3 domain in complex with inhibitor LCL-161
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-IUN:
LCL-161

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / Nuclear protein / inhibitor / histone H3 / DNA binding

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