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TitleSteric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide.
Journal, issue, pagesNucleic Acids Res., Vol. 51, Page 8880-8890, Year 2023
Publish dateDec 6, 2022 (structure data deposition date)
AuthorsTroisi, R. / Napolitano, V. / Rossitto, E. / Osman, W. / Nagano, M. / Wakui, K. / Popowicz, G.M. / Yoshimoto, K. / Sica, F.
External linksNucleic Acids Res. / PubMed:37503836
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-8bw5:
X-ray structure of the complex between human alpha thrombin and the duplex/quadruplex aptamer M08s-1_41mer
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-0G6:
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / DNA aptamer / G-quadruplex / duplex / duplex/quadruplex / thrombin binding aptamer / thrombin / coagulation factor / anticoagulant

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