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Title | A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity. |
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Journal, issue, pages | Nat Commun, Vol. 14, Page 4524-4524, Year 2023 |
Publish date | Apr 20, 2023 (structure data deposition date) |
Authors | Liang, S. / Tran, E. / Du, X. / Dong, J. / Sudholz, H. / Chen, H. / Qu, Z. / Huntington, N.D. / Babon, J.J. / Kershaw, N.J. ...Liang, S. / Tran, E. / Du, X. / Dong, J. / Sudholz, H. / Chen, H. / Qu, Z. / Huntington, N.D. / Babon, J.J. / Kershaw, N.J. / Zhang, Z.Y. / Baell, J.B. / Wiede, F. / Tiganis, T. |
External links | Nat Commun / PubMed:37500611 |
Methods | X-ray diffraction |
Resolution | 1.55 Å |
Structure data | PDB-8skl: |
Chemicals | ChemComp-CL: ChemComp-NA: ChemComp-V2O: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/INHIBITOR / PHOSPHATASE / HYDROLASE / HYDROLASE-INHIBITOR complex |