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-Structure paper
Title | Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 259, Page 115646-115646, Year 2023 |
Publish date | Apr 21, 2023 (structure data deposition date) |
Authors | Chebaiki, M. / Delfourne, E. / Tamhaev, R. / Danoun, S. / Rodriguez, F. / Hoffmann, P. / Grosjean, E. / Goncalves, F. / Azema-Despeyroux, J. / Pal, A. ...Chebaiki, M. / Delfourne, E. / Tamhaev, R. / Danoun, S. / Rodriguez, F. / Hoffmann, P. / Grosjean, E. / Goncalves, F. / Azema-Despeyroux, J. / Pal, A. / Kordulakova, J. / Preuilh, N. / Britton, S. / Constant, P. / Marrakchi, H. / Maveyraud, L. / Mourey, L. / Lherbet, C. |
External links | Eur. J. Med. Chem. / PubMed:37482022 |
Methods | X-ray diffraction |
Resolution | 1.6 - 1.962 Å |
Structure data | PDB-8otm: PDB-8otn: |
Chemicals | ChemComp-NAD: ChemComp-VZI: ChemComp-EDO: ChemComp-NA: ChemComp-ACT: ChemComp-HOH: ChemComp-VZR: |
Source |
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Keywords | OXIDOREDUCTASE / enoyl-ACP-reductase type II fatty acid synthase mycolic acids tuberculosis therapeutic target |