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TitleDesign of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.
Journal, issue, pagesJ. Med. Chem., Vol. 66, Page 10734-10745, Year 2023
Publish dateMay 19, 2023 (structure data deposition date)
AuthorsCardenas, E.L. / O'Rourke, R.L. / Menon, A. / Meagher, J. / Stuckey, J. / Garner, A.L.
External linksJ. Med. Chem. / PubMed:37471629
MethodsX-ray diffraction
Resolution1.986 Å
Structure data

PDB-8sx4:
Crystal Structure of eIF4e in complex with Compound 7n
Method: X-RAY DIFFRACTION / Resolution: 1.986 Å

Chemicals

ChemComp-WXL:
[(~{Z})-4-[2-azanyl-7-[(5-chloranyl-1~{H}-indol-2-yl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]but-2-enyl]phosphonic acid

ChemComp-M7G:
7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSLATION / eIF4e / translation initiation inhibitor

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