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TitleInsulin sensitization by small molecules enhancing GLUT4 translocation.
Journal, issue, pagesCell Chem Biol, Vol. 30, Page 933-942.e6, Year 2023
Publish dateApr 7, 2022 (structure data deposition date)
AuthorsYin, T.C. / Van Vranken, J.G. / Srivastava, D. / Mittal, A. / Buscaglia, P. / Moore, A.E. / Verdinez, J.A. / Graham, A.E. / Walsh, S.A. / Acevedo, M.A. ...Yin, T.C. / Van Vranken, J.G. / Srivastava, D. / Mittal, A. / Buscaglia, P. / Moore, A.E. / Verdinez, J.A. / Graham, A.E. / Walsh, S.A. / Acevedo, M.A. / Kerns, R.J. / Artemyev, N.O. / Gygi, S.P. / Sebag, J.A.
External linksCell Chem Biol / PubMed:37453421
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-7umo:
Structure of Unc119-inhibitor complex.
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NT6:
(3s,5s,7s)-N-(4,5-dichloropyridin-2-yl)adamantane-1-carboxamide

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / Unc119 / inhibitor

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