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-Structure paper
タイトル | Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A. |
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ジャーナル・号・ページ | Nat Commun, Vol. 14, Page 4196-4196, Year 2023 |
掲載日 | 2022年12月1日 (構造データの登録日) |
![]() | Chen, C.W. / Leimer, N. / Syroegin, E.A. / Dunand, C. / Bulman, Z.P. / Lewis, K. / Polikanov, Y.S. / Svetlov, M.S. |
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手法 | X線回折 |
解像度 | 2.35 - 2.65 Å |
構造データ | ![]() PDB-8fc1: ![]() PDB-8fc2: ![]() PDB-8fc3: ![]() PDB-8fc4: ![]() PDB-8fc5: ![]() PDB-8fc6: |
化合物 | ![]() ChemComp-MG: ![]() ChemComp-HGR: ![]() ChemComp-ERY: ![]() ChemComp-MPD: ![]() ChemComp-ARG: ![]() ChemComp-ZN: ![]() ChemComp-SF4: ![]() ChemComp-HOH: ![]() ChemComp-ZIT: ![]() ChemComp-TEL: |
由来 |
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![]() | RIBOSOME / Hygromycin A; macrolides; ketolides; erythromycin; azithromycin; telithromycin; antibiotic; synergy; Erm methyltransferase / X-ray structure; 70S ribosome; peptidyl transferase center; nascent peptide exit tunnel / Hygromycin A / macrolides / ketolides / erythromycin / azithromycin / telithromycin / antibiotic / synergy / Erm methyltransferase / 70S ribosome / peptidyl transferase center / nascent peptide exit tunnel |