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-Structure paper
Title | Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 9376-9400, Year 2023 |
Publish date | May 9, 2023 (structure data deposition date) |
![]() | Kuttruff, C.A. / Fleck, M. / Carotta, S. / Arnhof, H. / Bretschneider, T. / Dahmann, G. / Gremel, G. / Grube, A. / Handschuh, S. / Heimann, A. ...Kuttruff, C.A. / Fleck, M. / Carotta, S. / Arnhof, H. / Bretschneider, T. / Dahmann, G. / Gremel, G. / Grube, A. / Handschuh, S. / Heimann, A. / Hofmann, M.H. / Impagnatiello, M.A. / Nar, H. / Rast, G. / Schaaf, O. / Schmidt, E. / Oost, T. |
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Methods | X-ray diffraction |
Resolution | 2.094 Å |
Structure data | ![]() PDB-8p01: |
Chemicals | ![]() ChemComp-W78: ![]() ChemComp-HOH: |
Source |
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![]() | IMMUNE SYSTEM / agonist / complex / innate immune response |