EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
ジャーナル・号・ページ	Biochemistry, Vol. 62, Page 2182-2201, Year 2023
掲載日	2023年1月23日 (構造データの登録日)
著者	Glockzin, K. / Meneely, K.M. / Hughes, R. / Maatouk, S.W. / Pina, G.E. / Suthagar, K. / Clinch, K. / Buckler, J.N. / Lamb, A.L. / Tyler, P.C. ...Glockzin, K. / Meneely, K.M. / Hughes, R. / Maatouk, S.W. / Pina, G.E. / Suthagar, K. / Clinch, K. / Buckler, J.N. / Lamb, A.L. / Tyler, P.C. / Meek, T.D. / Katzfuss, A.
リンク	Biochemistry / PubMed:37418678
手法	X線回折
解像度	1.31 - 1.8 Å
構造データ	PDB-8fwy: Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to the dead-end complex xanthine and pyrophosphate 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å PDB-8fwz: Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Hydroxypropyl-Lin-ImmH Phosphonate 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-8fx0: Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to (S)-SerMe-ImmH Phosphonate 手法: X-RAY DIFFRACTION / 解像度: 1.52 Å PDB-8fx1: Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to (R)-SerMe-ImmH Phosphonate 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-8fx2: Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Immucillin-HP 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å PDB-8fx3: Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Immucillin-GP, showing the structure of the complete active site in its open conformation 手法: X-RAY DIFFRACTION / 解像度: 1.31 Å
化合物	ChemComp-XAN: XANTHINE / キサンチン ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-HOH: WATER ChemComp-YCE: [(2R)-2-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl]phosphonic acid ChemComp-YC9: [(3R)-4-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}butyl]phosphonic acid ChemComp-IRP: (1S)-1(9-DEAZAHYPOXANTHIN-9YL)1,4-DIDEOXY-1,4-IMINO-D-RIBITOL-5-PHOSPHATE / インムシリンHP ChemComp-IMU: PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER
由来	trypanosoma cruzi (strain cl brener) (トリパノソーマ)
キーワード	TRANSFERASE / Hypoxanthine-guanine-xanthine phosphoribosyltransferase / HGXPRT / TRANSFERASE/INHIBITOR / inhibitor / TRANSFERASE-INHIBITOR complex