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-Structure paper
| Title | Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 66, Page 9147-9160, Year 2023 |
| Publish date | Sep 27, 2022 (structure data deposition date) |
 Authors | Kettle, J.G. / Bagal, S.K. / Barratt, D. / Bodnarchuk, M.S. / Boyd, S. / Braybrooke, E. / Breed, J. / Cassar, D.J. / Cosulich, S. / Davies, M. ...Kettle, J.G. / Bagal, S.K. / Barratt, D. / Bodnarchuk, M.S. / Boyd, S. / Braybrooke, E. / Breed, J. / Cassar, D.J. / Cosulich, S. / Davies, M. / Davies, N.L. / Deng, C. / Eatherton, A. / Evans, L. / Feron, L.J. / Fillery, S. / Gleave, E.S. / Goldberg, F.W. / Cortes Gonzalez, M.A. / Guerot, C. / Haider, A. / Harlfinger, S. / Howells, R. / Jackson, A. / Johnstrom, P. / Kemmitt, P.D. / Koers, A. / Kondrashov, M. / Lamont, G.M. / Lamont, S. / Lewis, H.J. / Liu, L. / Mylrea, M. / Nash, S. / Niedbala, M.J. / Peter, A. / Phillips, C. / Pike, K. / Raubo, P. / Robb, G.R. / Ross, S. / Sanders, M.G. / Schou, M. / Simpson, I. / Steward, O. |
 External links | J. Med. Chem. / PubMed:37395055 |
| Methods | X-ray diffraction |
| Resolution | 1.11 - 1.7 Å |
| Structure data |  PDB-8b6i:  PDB-8b78: |
| Chemicals |  ChemComp-MG:  ChemComp-GDP:  ChemComp-PQI:  ChemComp-HOH:  ChemComp-PUO: |
| Source |
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 Keywords | SIGNALING PROTEIN / INHIBITOR COMPLEX |
homo sapiens (human)