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TitlePreclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity.
Journal, issue, pagesEbiomedicine, Vol. 93, Page 104663-104663, Year 2023
Publish dateDec 14, 2022 (structure data deposition date)
AuthorsHiemstra, I.H. / Santegoets, K.C.M. / Janmaat, M.L. / De Goeij, B.E.C.G. / Ten Hagen, W. / van Dooremalen, S. / Boross, P. / van den Brakel, J. / Bosgra, S. / Andringa, G. ...Hiemstra, I.H. / Santegoets, K.C.M. / Janmaat, M.L. / De Goeij, B.E.C.G. / Ten Hagen, W. / van Dooremalen, S. / Boross, P. / van den Brakel, J. / Bosgra, S. / Andringa, G. / van Kessel-Welmers, B. / Verzijl, D. / Hibbert, R.G. / Frerichs, K.A. / Mutis, T. / van de Donk, N.W.C.J. / Ahmadi, T. / Satijn, D. / Sasser, A.K. / Breij, E.C.W.
External linksEbiomedicine / PubMed:37379657
MethodsX-ray diffraction
Resolution1.85 Å
Structure data

PDB-8byu:
Crystal Structure of HexaBody-CD38 Fab in complex with CD38
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / CD38 / Antibody / CDC / HexaBody / Anti-Tumor

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