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Structure paper

TitleStructural evolution of an immune evasion determinant shapes pathogen host tropism.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 120, Page e2301549120-e2301549120, Year 2023
Publish dateApr 11, 2022 (structure data deposition date)
AuthorsMarcinkiewicz, A.L. / Brangulis, K. / Dupuis 2nd, A.P. / Hart, T.M. / Zamba-Campero, M. / Nowak, T.A. / Stout, J.L. / Akopjana, I. / Kazaks, A. / Bogans, J. ...Marcinkiewicz, A.L. / Brangulis, K. / Dupuis 2nd, A.P. / Hart, T.M. / Zamba-Campero, M. / Nowak, T.A. / Stout, J.L. / Akopjana, I. / Kazaks, A. / Bogans, J. / Ciota, A.T. / Kraiczy, P. / Kolokotronis, S.O. / Lin, Y.P.
External linksProc. Natl. Acad. Sci. USA / PubMed:37364114
MethodsX-ray diffraction
Resolution2.1 - 2.59 Å
Structure data

PDB-7zjj:
CspZ (BbCRASP-2) from Borrelia burgdorferi strain B379
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-7zjk:
CspZ (BbCRASP-2) from Borrelia burgdorferi strain B408
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-7zjm:
Crystal structure of a complex between CspZ from Borrelia burgdorferi strain B408 and human FH SCR domains 6-7
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

Chemicals

ChemComp-NO3:
NITRATE ION

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-IMD:
IMIDAZOLE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • borreliella burgdorferi (Lyme disease spirochete)
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Lyme disease / borreliosis / outer surface protein / BBH06 / complement binding. / complement binding / IMMUNE SYSTEM / complement system / BBH06.

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