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-Structure paper
Title | Discovery of pyrrolo[2,1- f ][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain. |
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Journal, issue, pages | Med. Chem. Res., Page 1-7, Year 2023 |
Publish date | Mar 24, 2023 (structure data deposition date) |
Authors | Dzierba, C.D. / Dasgupta, B. / Karageorge, G. / Kostich, W. / Hamman, B. / Allen, J. / Esposito, K.M. / Padmanabha, R. / Grace, J. / Lentz, K. ...Dzierba, C.D. / Dasgupta, B. / Karageorge, G. / Kostich, W. / Hamman, B. / Allen, J. / Esposito, K.M. / Padmanabha, R. / Grace, J. / Lentz, K. / Morrison, J. / Morgan, D. / Easton, A. / Bourin, C. / Browning, M.R. / Rajamani, R. / Good, A. / Parker, D.D. / Muckelbauer, J.K. / Khan, J. / Camac, D. / Ghosh, K. / Halan, V. / Lippy, J.S. / Santone, K.S. / Denton, R.R. / Westphal, R. / Bristow, L.J. / Conway, C.M. / Bronson, J.J. / Macor, J.E. |
External links | Med. Chem. Res. / PubMed:37362320 |
Methods | X-ray diffraction |
Resolution | 2.2 - 2.5 Å |
Structure data | PDB-8gmc: PDB-8gmd: |
Chemicals | ChemComp-YFV: ChemComp-SO4: ChemComp-HOH: ChemComp-ZRR: |
Source |
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Keywords | TRANSFERASE / AP2 ASSOCIATED KINASE 1 / AAK1 / kinase / ligand inhibitor |