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Structure paper

TitleCisplatin binding to angiogenin protein: new molecular pathways and targets for the drug's anticancer activity.
Journal, issue, pagesDalton Trans, Vol. 52, Page 9058-9067, Year 2023
Publish dateApr 4, 2023 (structure data deposition date)
AuthorsFerraro, G. / Sanfilippo, V. / Chiaverini, L. / Satriano, C. / Marzo, T. / Merlino, A. / La Mendola, D.
External linksDalton Trans / PubMed:37337706
MethodsX-ray diffraction
Resolution1.76 - 1.99 Å
Structure data

PDB-8oo3:
X-ray structure of the adduct formed upon reaction of cisplatin with human angiogenin after 5 days soaking
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-8oo4:
X-ray structure of the adduct formed upon reaction of cisplatin with human angiogenin after 1 month soaking
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-NH3:
AMMONIA

ChemComp-PT:
Unknown entry

ChemComp-TAR:
D(-)-TARTARIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / angiogenin / CDDP / ROS production / prostate cancer

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