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Structure paper

TitleA highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer.
Journal, issue, pagesJ Immunother Cancer, Vol. 11, Year 2023
Publish dateJun 13, 2023 (structure data deposition date)
AuthorsLiu, J. / Chiang, H.C. / Xiong, W. / Laurent, V. / Griffiths, S.C. / Dulfer, J. / Deng, H. / Sun, X. / Yin, Y.W. / Li, W. ...Liu, J. / Chiang, H.C. / Xiong, W. / Laurent, V. / Griffiths, S.C. / Dulfer, J. / Deng, H. / Sun, X. / Yin, Y.W. / Li, W. / Audoly, L.P. / An, Z. / Schurpf, T. / Li, R. / Zhang, N.
External linksJ Immunother Cancer / PubMed:37328286
MethodsX-ray diffraction
Resolution3.152 Å
Structure data

PDB-8pe9:
Complex between DDR1 DS-like domain and PRTH-101 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.152 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ZN:
Unknown entry

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Humanized antibody / DDR1 / collagen / immune exclusion / breast cancer

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