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TitlePregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.
Journal, issue, pagesNat Commun, Vol. 14, Page 3368-3368, Year 2023
Publish dateJul 8, 2022 (structure data deposition date)
AuthorsFan, S. / Yan, Y. / Xia, Y. / Zhou, Z. / Luo, L. / Zhu, M. / Han, Y. / Yao, D. / Zhang, L. / Fang, M. ...Fan, S. / Yan, Y. / Xia, Y. / Zhou, Z. / Luo, L. / Zhu, M. / Han, Y. / Yao, D. / Zhang, L. / Fang, M. / Peng, L. / Yu, J. / Liu, Y. / Gao, X. / Guan, H. / Li, H. / Wang, C. / Wu, X. / Zhu, H. / Cao, Y. / Huang, C.
External linksNat Commun / PubMed:37291126
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-7yfk:
The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-G3L:
Nomilin

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Complex / Activator / Drug Binding / Nuclear Receptor

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