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TitleMechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics.
Journal, issue, pagesNucleic Acids Res., Vol. 51, Page 6738-6753, Year 2023
Publish dateJan 28, 2022 (structure data deposition date)
AuthorsHoitsma, N.M. / Norris, J. / Khoang, T.H. / Kaushik, V. / Chadda, R. / Antony, E. / Hedglin, M. / Freudenthal, B.D.
External linksNucleic Acids Res. / PubMed:37264933
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-7tr7:
APE1 product complex with abasic ssDNA
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsLYASE/DNA / DNA Repair / Abasic ssDNA / AP-Endonuclease / LYASE / LYASE-DNA complex

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