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Structure paper

TitleProtein oxidation increases SAMHD1 binding ssDNA via its regulatory site.
Journal, issue, pagesNucleic Acids Res., Vol. 51, Page 7014-7024, Year 2023
Publish dateJun 9, 2022 (structure data deposition date)
AuthorsSimermeyer, T.L. / Batalis, S. / Rogers, L.C. / Zalesak, O.J. / Hollis, T.
External linksNucleic Acids Res. / PubMed:37246644
MethodsX-ray diffraction
Resolution2.44 - 2.82 Å
Structure data

PDB-8d94:
SAMHD1-DNA complex
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

PDB-8d9j:
SAMHD1-DNA complex
Method: X-RAY DIFFRACTION / Resolution: 2.82 Å

Chemicals

ChemComp-FE:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE/DNA / DNA complex / catalytic domain / dNTP hydrolysis / ANTIVIRAL PROTEIN / HYDROLASE-DNA complex

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