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TitleDevelopment of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis.
Journal, issue, pagesPharmaceuticals, Vol. 16, Year 2023
Publish dateFeb 3, 2023 (structure data deposition date)
AuthorsWubben, T.J. / Chaudhury, S. / Watch, B.T. / Stuckey, J.A. / Weh, E. / Fernando, R. / Goswami, M. / Pawar, M. / Rech, J.C. / Besirli, C.G.
External linksPharmaceuticals / PubMed:37242488
MethodsX-ray diffraction
Resolution1.838 Å
Structure data

PDB-8g2e:
PKM2 bound to compound 2
Method: X-RAY DIFFRACTION / Resolution: 1.838 Å

Chemicals

ChemComp-YII:
3-[(3-aminophenyl)methyl]-5-methyl-7-[methyl(oxidanyl)-$l^{3}-sulfanyl]pyridazino[4,5-b]indol-4-one

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-OXL:
OXALATE ION

ChemComp-SO4:
SULFATE ION

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / activator / small molecule

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